Human Stem Cell Factor/Mast Cell Growth Factor, SCF/MGF ELI

Ligand for the receptor-type protein-tyrosine kinase KIT.

Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

KITLG/SCF binding can activate several signaling pathways.

Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1.

KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.

KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.

KITLG/SCF acts synergistically with other cytokines, probably interleukins.