Human Steroid Hormone Receptor Err1, ESRRA ELI

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'.

Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter.

Binds to the C1 region of the lactoferrin gene promoter.

Requires dimerization and the coactivator, PGC-1A, for full activity.

The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.

Induces the expression of PERM1 in the skeletal muscle.