Human Sterol-O-Acyltransferase 1, SOAT1 ELI

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed: 16154994, PubMed: 16647063, PubMed: 9020103, PubMed: 32433614, PubMed: 32433613).

Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed: 16154994, PubMed: 9020103).

Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed: 11294643, PubMed: 32433614).