Human Sterol Regulatory Element-binding Protein 2, SREBF2 ELI
3,140.00 ₪
[Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed: 32322062).
Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed: 32322062).
[Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed: 12177166, PubMed: 32322062).
Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').
Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed: 7903453, PubMed: 12177166).
Regulates transcription of genes related to cholesterol synthesis pathway (PubMed: 12177166, PubMed: 32322062).
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