Human STK4 Primacu™ ELI

Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis.

STK4/Hippo pathway may have important therapeutic implications for cancer.

The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC).

STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.