Human Structural Maintenance of Chromosomes Protein 3, SMC3 ELI

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle.

The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped.

At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.

Cohesion is coupled to DNA replication and is involved in DNA repair.

The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.