Human Supervillin, SVIL ELI

Forms a high-affinity link between the actin cytoskeleton and the membrane.

Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly.

May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration.

May play a role in invadopodial function (PubMed:19109420). May be involved in modulation of focal adhesions.

Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6.

Plays a role in cytokinesis through KIF14 interaction (By similarity).