Human Suppressors of Cytokine Signaling 1, SOCS1 ELI

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.

SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.

Through binding to JAKs, inhibits their kinase activity.

In vitro, also suppresses Tec protein-tyrosine activity.

Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).

Regulates interferon-gamma mediated sensory neuron survival (By similarity).

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Seems to recognize JAK2.

SOCS1 appears to be a negative regulator in IGF1R signaling pathway.