Human Suppressors of Cytokine Signaling 3, SOCS-3 ELI

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.

SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.

Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors.

Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling.

Suppresses fetal liver erythropoiesis.

Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity).

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 15601820).