Human T-Box Protein 6,TBX6 ELI

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal.

Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development.

Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

{ECO:0000250}.