Human Teratocarcinoma Derived Growth Factor 1, TDGF1 ELI

GPI-anchored cell membrane protein involved in Nodal signaling.

Cell-associated TDGF1 acts as a Nodal coreceptor in cis.

Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed: 27881714).

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed: 11909953).