Human Tetraspanin 30Cluster of Differentiation 63,CD63 ELI

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades.

Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases.

Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2.

Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2.

Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes.

Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking.

May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

{ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.