Human TGFB-inducible early growth response protein 1,TIEG1 ELI

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'.

Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.

Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver.

Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity).

May play a role in the cell cycle regulation.

{ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.