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Human Thiopurine methyltranferase,TPMT ELI
Price
3,140.00 ₪
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748).
TPMT activity modulates the cytotoxic effects of thiopurine prodrugs.
A natural substrate for this enzyme has yet to be identified.
{ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}.
Quantity
Storage and Stability
2-8ºC
Sensitivity
0.018ng/ml
Detection range
0.05-15ng/ml
Shipping Conditions
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