Human Thioredoxin-interacting Protein, TXNIP ELI

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability.

Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm.

Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest.

Required for the maturation of natural killer cells.

Acts as a suppressor of tumor cell growth.

Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).