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Human Toll Interacting Protein, TOLLIP ELI

Price

‏3,140.00 ‏₪

Component of the signaling pathway of IL-1 and Toll-like receptors.

Inhibits cell activation by microbial products.

Recruits IRAK1 to the IL-1 receptor complex.

Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates.

The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

Package Size

Quantity

Storage and Stability

2-8ºC

Sensitivity

5.18ng/L

Detection range

10-2000ng/L

Shipping Conditions

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