Human Toll-like Receptor 3, TLR3 ELI

Key component of innate and adaptive immunity.

TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms.

TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.

Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.