Human Transcription Factor 7 Like Protein 2,TCF7L2 ELI

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner.

Acts as repressor in the absence of CTNNB1, and as activator in its presence.

Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1.

TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1.

Expression of dominant-negative mutants results in cell-cycle arrest in G1.

Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

{ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.