Human Transcription Factor A, Mitochondrial, TFAM ELI
3,140.00 ₪
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed: 29445193, PubMed: 32183942).
Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed: 29149603).
In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed: 20410300).
Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed: 22037172).
Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed: 22037172).
Is able to unwind DNA (PubMed: 22037172).
Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed: 1737790).
Required for maintenance of normal levels of mitochondrial DNA (PubMed: 22841477, PubMed: 19304746).
May play a role in organizing and compacting mitochondrial DNA (PubMed: 22037171).
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