Human Transcription Factor Pu.1, SPI1 ELI

Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer.

This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells.

Also binds RNA and may modulate pre-mRNA splicing (By similarity).