Human Transient Receptor Potential Cation Channel Subfamily V, Member 2, TRPV2 E

Calcium-permeable, non-selective cation Channel with an outward rectification.

Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator.

May transduce physical stimuli in mast cells.

Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.