Human Transient Receptor Potential Melastatin-4,TRPM4 ELI

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822).

While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988).

Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane.

It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc.

Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.

Involved in myogenic constriction of cerebral arteries.

Controls insulin secretion in pancreatic beta-cells.

May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.

Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization.

Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

Plays a role in keratinocyte differentiation (PubMed:30528822).

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