Human Trichoplein Keratin Filament-binding Protein, TCHP ELI

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.

Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation.

May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery.

May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed: 15731013, PubMed: 18931701).

Is a negative regulator of ciliogenesis (PubMed: 25270598).