Human Tropomyosin Beta Chain, TPM2 ELI

Binds to actin filaments in muscle and non-muscle cells.

Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.

Smooth muscle contraction is regulated by interaction with caldesmon.

In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

The non-muscle isoform may have a role in agonist-mediated receptor internalization.