Human Tumor-associated Calcium Signal Transducer 2, TACSTD2 ELI

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene.

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733.

This antigen is a member of a family including at least two type I membrane proteins.

It transduces an intracellular calcium signal and acts as a cell surface receptor.