Human tumor necrosis factor receptor 1,TNF-R1 ELI

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha.

The adapter molecule FADD recruits caspase-8 to the activated receptor.

The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.