Human Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14 ELI

Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed: 9462508, PubMed: 10754304, PubMed: 18193050, PubMed: 23761635).

Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed: 19915044, PubMed: 9153189, PubMed: 9162022).

Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes.

In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed: 10754304).

Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed: 23761635).

In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).

Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed: 18193050).

May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed: 19915044) (By similarity).

In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed: 19915044) (By similarity).

(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.

(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.