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Human Tumor necrosis factor receptor superfamily member 6,FAS ELI

Price

‏3,140.00 ‏₪

Receptor for TNFSF6/FASLG.

The adapter molecule FADD recruits caspase-8 to the activated receptor.

The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

The secreted isoforms 2 to 6 block apoptosis (in vitro).

{ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.

Package Size

Quantity

Storage and Stability

2-8ºC

Sensitivity

54.2ng/L

Detection range

100-6400ng/L

Shipping Conditions

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