Human Tumor Susceptibility Gene 101 Protein, TSG101 ELI

Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).

Mediates the association between the ESCRT-0 and ESCRT-I complex.

Required for completion of cytokinesis; the function requires CEP55.

May be involved in cell growth and differentiation.

Acts as a negative growth regulator.

Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P.

This interaction is essential for viral particle budding of numerous retroviruses.

Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed: 22660413).

It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed: 22315426).