Human Tyrosine-protein Kinase Tec, TEC ELI

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton.

Plays a redundant role to ITK in regulation of the adaptive immune response.

Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.

Required for TCR-dependent IL2 gene induction.

Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling.

Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking.

Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein.

Required in mast cells for efficient cytokine production.

Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells.

Participates in platelet signaling downstream of integrin activation.

Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription.

GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC.

TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets.

Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway.

TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'.

May also be involved in the regulation of osteoclast differentiation.