Human Tyrosine Protein Phosphate Non-receptor Type 22, PTPN22 ELI

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed: 16461343, PubMed: 18056643).

Associates with and probably dephosphorylates CBL.

Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed: 21719704).

Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed: 16461343).

Dephosphorylates the immune system activator SKAP2 (PubMed: 21719704).

Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed: 23871208).

Promotes host antiviral responses mediated by type 1 interferon (By similarity).

Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed: 23991106).

Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).