Human Ubiquitin-associated and Sh3 Domain-containing Protein A, UBASH3A ELI

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases.

Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.

Exhibits negligigle protein tyrosine phosphatase activity at neutral pH.

May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.

May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.