Human Ubiquitin Carboxyl-terminalhydrolase Isozyme L1, UCHL1 ELI

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable).

This enzyme is a thiol protease that recognizes and hydrolyzes a Peptide bond at the C-terminal glycine of ubiquitin (PubMed: 9774100, PubMed: 8639624, PubMed: 12408865, PubMed: 23359680).

Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).

The homodimer may have ATP-independent ubiquitin ligase activity (PubMed: 12408865).