Human Ubiquitin Conjugating Enzyme E2 C,UBE2C ELI

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination.

Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.

Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

{ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}.