Human Ubiquitin-fold modifier 1,UFM1 ELI
3,140.00 ₪
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677).
The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677).
Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526).
Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (PubMed:25219498).
{ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29868776, ECO:0000269|PubMed:32160526}.
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