Human V-set Domain-containing T-cell Activation Linhibitor 1, VTCN1 ELI

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity.

When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity.

Involved in promoting epithelial cell transformation.