Human Vascular Endothelial Cell Growth Factor A, VEGF-A ELI

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.

Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.

Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin.

NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.

Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).