Human Wd Repeat- and Fyve Domain-containing Protein 4, WDFY4 ELI

Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells.

Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking.

Plays also a role in B-cell survival through regulation of autophagy.