Human Wilms Tumor Protein 1,WT1 ELI

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533).

Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363).

Regulates the expression of numerous target genes, including EPO.

Plays an essential role for development of the urogenital system.

It has a tumor suppressor as well as an oncogenic role in tumor formation.

Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190).

Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801).

Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

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