Human Zinc Finger E-Box-binding Homeobox 1, ZEB1 ELI

Acts as a transcriptional repressor.

Inhibits interleukin-2 (IL-2) gene expression.

Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.

Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1.

Represses BCL6 transcription in the presence of the corepressor CTBP1.

Positively regulates neuronal differentiation.

Represses RCOR1 transcription activation during neurogenesis.

Represses transcription by binding to the E box (5'-CANNTG-3').

Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.