Human Zinc Finger Protein Gli1, GLI1 ELI

Acts as a transcriptional activator (PubMed: 19706761, PubMed: 10806483, PubMed: 19878745, PubMed: 24311597, PubMed: 24217340).

Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed: 2105456, PubMed: 8378770, PubMed: 24217340).

Regulates the transcription of specific genes during normal development (PubMed: 19706761).

Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract.

Mediates SHH signaling (PubMed: 19706761, PubMed: 28973407).

Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed: 11238441, PubMed: 28973407).

[Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1.

Activates expression of CD24, unlike isoform 1.

Mediates SHH signaling.

Promotes cancer cell migration.