Mouse antigen KI-67,MKI67 ELI
3,140.00 ₪
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226).
Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity).
Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251).
May play a role in chromatin organization (PubMed:26949251).
It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.
{ECO:0000250|UniProtKB:P46013, ECO:0000269|PubMed:26949251, ECO:0000269|PubMed:27362226, ECO:0000305}.
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