Mouse Apelin receptor,APLNR ELI
3,140.00 ₪
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity.
Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28854362, PubMed:28890073, PubMed:28663440).
May promote angioblast migration toward the embryonic midline, i.e.
the position of the future vessel formation, during vasculogenesis (By similarity).
Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073).
Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:28371822).
{ECO:0000250|UniProtKB:P79960, ECO:0000250|UniProtKB:Q7SZP9, ECO:0000269|PubMed:28371822, ECO:0000269|PubMed:28663440, ECO:0000269|PubMed:28854362, ECO:0000269|PubMed:28890073}.
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