Mouse Apoptosis regulator Bcl-2,Bcl2 ELI

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells.

Regulates cell death by controlling the mitochondrial membrane permeability.

Appears to function in a feedback loop system with caspases.

Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

{ECO:0000269|PubMed:17418785}.