Mouse ATPase, Ca++ Transporting, Plasma Membrane 2,ATP2B2 ELI

ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038).

Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment.

Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513).

At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise.

Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513).

Plays an essential role in hearing and balance.

In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels.

Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:9668038) (By similarity).

Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity).

In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868).

{ECO:0000250|UniProtKB:Q01814, ECO:0000269|PubMed:15302868, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:17409239, ECO:0000269|PubMed:20083513, ECO:0000269|PubMed:9668038}.