Mouse Autophagy related protein 14,ATG14 ELI

Required for both basal and inducible autophagy (PubMed:19270696, PubMed:19270693).

Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity).

Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:19270693).

Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity).

Enhances PIK3C3 activity in a BECN1-dependent manner.

Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity).

Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation of PIK3C3 by AMPK (PubMed:23332761).

Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (By similarity).

Modulates the hepatic lipid metabolism (PubMed:22992773).

{ECO:0000250|UniProtKB:Q6ZNE5, ECO:0000269|PubMed:19270693, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22992773, ECO:0000269|PubMed:23332761}.