Mouse Autophagy related protein 16-like 1,ATG16L1 ELI
3,140.00 ₪
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II.
Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225).
Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity).
Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340).
Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway.
Plays a role in regulating morphology and function of Paneth cell.
{ECO:0000250|UniProtKB:Q676U5, ECO:0000269|PubMed:12665549, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904}.
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