Mouse Autophagy Related Protein 9A, ATG9A ELI

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation.

Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.

Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes.

Nutrient starvation induces accumulation on autophagosomes.

Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity).

Required for carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced ATG8 family proteins lipidation, a key autophagy step.