Mouse Beta-Site APP Cleaving Enzyme 1,bACE1 ELI

Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091).

Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091).

Cleaves CHL1 (PubMed:29325091).

{ECO:0000269|PubMed:29325091}.