Mouse Bone Morphogenetic Protein 2,BMP2 ELI

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis.

Induces cartilage and bone formation.

Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.

Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A.

In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation.

Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.

{ECO:0000250|UniProtKB:P12643}.